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Department of Radiology

Dr Pelc Elected as AIMBE Director At-Large

Thumbnail image for Norbert PelcNorbert Pelc, PhD has been elected by his peers, leaders in the fields of medical and biological engineering, as the Director At-Large of the American Institute for Medical and Biological Engineering (AIMBE) for 2014 - 2016. AIMBE’s mission is to recognize excellence in, and advocate for, the fields of medical and biological engineering in order to advance society.

Congratulations, Dr. Pelc!

Read the AIMBE Press Release

First of Its Kind Brain Imaging Shows Cultural Differences

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Top row: differences between US and Koreans in solving moral dilemmas;
Middle row: differences between people solving personal vs. impersonal moral dilemmas;
Bottom row: interaction of group by dilemma type, showing anterior cingulate (associated with conflict monitoring)

Hyemin Han, a graduate advisee of Dr. Gary Glover, has published an article in Behavioural Brain Research that offers a first look at neural differences between cultural groups solving tricky moral problems. Han's study, "Cultural influences on the neural correlate of moral decision making processes", compares neural activity of moral reasoning between different cultural groups while other researchers have used fMRI to identify the brain regions involved in moral thinking in a single cultural group or compared the moral thought processes between cultures using survey or other, non-imaging, methods.

Read the Stanford Report article
Read the Behavioural Brain Research article

New MRI Technique Could Offer Radiation-free Alternative for Visualising Cancerous Tumours in Children

conceptual artistic rendering of radiation-free whole body pediatric MRIIn The Lancet Oncology, our research team reports that a new whole body diffusion weighted MRI scanning technique, which uses an iron supplement (ferumoxytol) to enhance tumour visibility, is just as effective as PET/CT imaging in the detection of malignant tumors in pediatric patients, with comparable sensitivities, specificities, and diagnostic accuracy. Average exposure to ionising radiation was 12.5 mSv for 18F-FDG PET/CT compared with zero for whole-body MRI. Saving radiation exposure from diagnostic scans is particularly relevant for children, because they are more radiosensitive than adults and live long enough to encounter radiation-induced secondary cancers.

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Research Featured on Cover of the Journal Small

Small, volume 10, issue 3, journal coverThe journal Small featured the collaborative work from the Daldrup-Link Lab and the Rao Lab on their cover. The article is entitled, "Cancer Therapy: Development of Novel Tumor-Targeted Theranostic Nanoparticles Activated by Membrane-Type Matrix Metalloproteinases for Combined Cancer Magnetic Resonance Imaging and Therapy".

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First in the World Time-of-flight PET-MRI Scanner Arrives at Stanford

Photo of Stanford's new PET-MR scannerIn December of 2013, we received the first whole body time-of-flight PET-MRI scanner, capable of simultaneous PET and MR imaging. The PET-MR device is located at the Richard M. Lucas Center for Imaging. Stanford Radiology is a known leader in the field of advanced MRI techniques for both neurological and whole body imaging, much of which is undertaken under the auspices of the Lucas Center, led by Gary Glover, PhD. Stanford Radiology has also long been a leader in the field of molecular imaging, as evidenced by the success of the Molecular Imaging Program at Stanford (MIPS) led by Sanjiv Sam Gambhir, MD, PhD. Thus, we are the natural site to fully exploit the potential of this new PET-MRI scanner.

During the past several years, we have built a working group developing PET and MRI research projects to prepare for the use of this remarkable machine and to advise the scientists and engineers who were developing it. This group, co-led by Greg Zaharchuk, MD, PhD and Andrei Iagaru, MD, consists of radiologists, nuclear medicine physicians, and scientists focusing on all of the major applications of PET-MRI, including oncology, cardiac, musculoskeletal, and neurological applications, both for adult and pediatric patients, as well as technical development and innovation. Additionally, a clinical hyperpolarizer will soon be added to the machine, enabling hyperpolarized carbon-13 metabolomic imaging to be combined in real-time with PET-MRI. This exciting research journey will capture the specific benefits of combined PET-MRI and will allow meaningful future clinical use of this new imaging technology.

Simultaneous PET-MRI may improve clinical outcomes through improved diagnostic accuracy, therapy planning, and disease monitoring. We are excited and highly motivated by this opportunity and welcome everyone interested to contribute to its growth and success at Stanford and worldwide.

Dr Plevritis Elected to AIMBE College of Fellows

Photo of Sylvia PlevritisSylvia Plevritis, PhD has been elected by her peers, leaders in the fields of medical and biological engineering, to the American Institute for Medical and Biological Engineering (AIMBE) 2014 College of Fellows. She will be inducted during AIMBE's annual meeting in March.

Congratulations, Dr. Plevritis!

Dr McDougall Received the Light of Life Award

Photo of Ross McDougallRoss McDougall, MD has received the Light of Life Award from Memorial Sloan Kettering Cancer Center where he gave a lecture entitled, "Differentiated Thyroid Cancer, Then and Now: Four Questions and a Quandary".

The Light of Life Award is an annual award presented to an esteemed physician in thyroid cancer research as selected by the Light of Life Foundation. Their mission is to improve the quality of life of thyroid cancer patients through continual education of the lay public and the medical community, and by promoting research and development to improve thyroid cancer care. The Light of Life Foundation Honorary Award has become recognized amongst the worldwide thyroid cancer medical community.

Congratulations, Dr. McDougall!

RSNA 2013 Molecular Imaging Travel Award Recipients

Congratulations to the following 2013 Radiology Society of North America Molecular Imaging Travel Award recipients:

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Aman Khurana, MD - "In Vivo Mesenchymal Stem Cell Labeling Using FDA Approved Iron Oxide: Ferumoxytol"

 

Photo of Ferdinand Knieling
Ferdinand Knieling - "Non-invasive Assessment of Inflammation in a Murine Model of Chronic Inflammatory Bowel Disease Using Ultrasound Molecular Imaging"

 

Photo of Steven Machtaler
Steven Machtaler, PhD - "Utilization of Ultrasound Molecular Imaging Targeted to Thy1(CD90) for the Detection of Pancreatic Ductal Adenocarcinoma in an Orthotopic Murine Xenograft Model"

 

Photo of Adam Shuhendler
Adam J. Shuhendler, PhD - "Building Nanoparticles from Small Molecules in Situ in Dying Tumor Tissue to Track Chemotherapy Response by MRI"

 

Fanny Chapelin Received France "Best Engineer of the Year" Award

Photo of Fanny ChapelinOut of a national selection among thousands of engineers, Fanny Chapelin, was awarded the France "Best Engineer of the Year" award, in the category of "science" organized by L'Usine Nouvelle and Industry & Technology. The purpose of this award is to promote engineering studies and show it's diversity in applications and to encourage future generations to pursue careers in science by recognizing great French scientists. The last round of selection was based on a five page dissertation about a project the engineer pursued in the past years and what impact it will have for people. Fanny's dissertation discussed a new in vivo stem cell labeling technique for tracking stem cells after transplantation that's ready for the clinics.

Brief description of the project:
"Our new method addresses an important bottleneck for safe clinical translation of novel stem cell therapies. Transplanted stem cells need to be tracked in vivo in order to ensure safe deposition and lack of tumor formation. However, previously applied labeling procedures of stem cells with contrast agents or radiotracers required stem cell manipulations between their harvest and transplantation, which poses risks of contaminations and biological alterations of the cells. We present a novel approach of "in vivo" stem cell labeling, which relies on a simple parenteral administration of an FDA-approved iron supplement 1-2 days before a planned harvest of mesenchymal stem cells (MSC) from bone marrow. Our data show that the iron compound is taken up by MSC, is retained in MSC through harvesting and ex vivo expansion procedures and that it allows for sensitive in vivo stem cell tracking with magnetic resonance (MR) imaging. To the best of our knowledge, this is the first report of "in vivo" stem cell labeling with an immediately clinically applicable iron supplement. This approach could be immediately translated to the clinic and could be widely utilized to track MSC transplants in various target organs of patients."

Fanny was the youngest ever nominated, the only woman nominated and the only award winning woman.

Congratulations, Fanny!

Read the L'Usine Nouvelle article
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Resident, Lina Nayak's, Work Featured by Aunt Minnie

Radiology Breast Imaging resident, Lina Nayak, was the lead author of an article published in the December 2013 issue of Academic Radiology. The article, which discusses the importance of imagery in radiology reports to referring physicians, was covered by Aunt Minnie. Dr. Nayak's research concludes that "creating accessible, readable, and automatic multimedia reports should be a high priority to enhance the practice and satisfaction of referring physicians, improve patient care, and emphasize the critical role radiology plays in current medical care."

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