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Department of Radiology

Dr. Brooke Jeffrey Received Society of Abdominal Radiology Lifetime Achievement Award

Photo of Brooke JeffreyPlease join us in congratulating Dr. Brooke Jeffrey who was recognized by the Society of Abdominal Radiology and received the SAR Lifetime Achievement Award. The Lifetime Achievement Award is bestowed upon any present or past member of the Society for their substantial contributions to abdominal radiology.

Congratulations, Dr. Jeffrey, on this terrific and well deserved honor!

Dr. Daldrup-Link Elected to the American Society for Clinical Investigation (ASCI)

daldrupLinkHeike_6.13.jpgPlease join us in congratulating Dr. Heike Daldrup-Link in her election to the American Society for Clinical Investigation (ASCI)! She was nominated by ASCI members Dr. Sanjiv Sam Gambhir and Dr. Linda Boxer for her contributions in the field of translational cellular imaging.

Dr. Daldrup-Link introduced tumor characterizations via the enhanced permeability and retention effect and lead a first multi-center clinical trial on nanoparticle-enhanced MR imaging of breast cancer to prove this concept in patients. She discovered a new approach for MR imaging of tumor associated macrophages (TAM) with iron oxide nanoparticles in mouse models and obtained an IND to carry out the first TAM imaging trial in pediatric patients. This approach will be used in the future to monitor new anti-CD47 mAb immunotherapies in patients. In collaboration with Dr. Rao, Dr. Daldrup-Link developed tumor-enzyme activatable theranostic nanoparticles, without side effects for combined cancer imaging and therapy. She recently introduced a novel radiation-free whole body staging test for children with cancer (Lancet Oncology 2014). Dr. Daldrup-Link's cellular imaging studies also yielded several new and patented ideas for in vivo imaging of stem cell transplants, establishing immediately clinically applicable technologies for: in vivo stem cell tracking with FDA-approved nanoparticles, in vivo imaging of stem cell rejection processes with immune-cell targeted tracers, and MRI-detection of stem cell apoptosis with a caspase-activatable contrast agent. These cellular imaging tools provide a truly new way to evaluate stem cell physiology beyond simple cell detection, expanding our understanding of in vivo stem cell engraftment outcomes.

The ASCI is one of the nationís oldest and most respected medical honor societies of physician-scientists, those who translate findings in the laboratory to the advancement of clinical practice. Founded in 1908, the Society is home to more than 3,000 physician-scientists from all medical specialties elected to the Society for their outstanding records of scholarly achievement in biomedical research. The ASCI represents active physician-scientists who are at the bedside, at the research bench, and at the blackboard. Many of its senior members are widely recognized leaders in academic medicine.

The ASCI is dedicated to the advancement of research that extends our understanding and improves the treatment of human diseases, and members are committed to mentoring future generations of physician-scientists. The ASCI considers the nominations of several hundred physician-scientists submitted from among its members each year and elects up to 80 new members each year for their significant research accomplishments. Because members must be 50 years of age or younger at the time of their election, membership reflects accomplishments by its members relatively early in their careers.

Congratulations, Dr. Daldrup-Link!

Dr Kim Butts Pauly Elected to the AIMBE College of Fellows

Photo of Kim Butts PaulyThe American Institute for Medical and Biological Engineering (AIMBE) has announced the pending induction of Kim Butts Pauly, PhD, Professor of Radiology and Co-Director of Radiological Sciences Laboratory, to its College of Fellows. Dr. Butts Pauly was nominated, reviewed, and elected by peers and members of the College of Fellows For outstanding contributions to the development of magnetic resonance imaging techniques, particularly for monitoring minimally invasive procedures. Dr. Butts Pauly is the 23rd Stanford AIMBE fellow named since 1992 and only the 4th Stanford woman to be named.

The College of Fellows is comprised of the top two percent of medical and biological engineers in the country. The most accomplished and distinguished engineering and medical school chairs, research directors, professors, innovators, and successful entrepreneurs, comprise the College of Fellows.

AIMBE Fellows are regularly recognized for their contributions in teaching, research, and innovation. AIMBE Fellows have been awarded the Presidential Medal of Science and the Presidential Medal of Technology and Innovation and many also are members of the National Academy of Engineering, Institute of Medicine, and the National Academy of Sciences.

A formal induction ceremony will be held during AIMBEís 2015 Annual Meeting at the National Academy of Sciences Great Hall in Washington, DC on March 16, 2015.

AIMBEís mission is to recognize excellence in, and advocate for, the fields of medical and biological engineering in order to advance society. Since 1991, AIMBEĎs College of Fellows has lead the way for technological growth and advancement in the fields of medical and biological engineering. Fellows have helped revolutionize medicine and related fields in order to enhance and extend the lives of people all over the world. They have also successfully advocated for public policies that have enabled researchers and business-makers to further the interests of engineers, teachers, scientists, clinical practitioners, and ultimately, patients.

Research Featured as the Inside Cover in the Advanced Materials

AM-cover-150204.jpgThe paper entitled "Perylene-Diimide-Based Nanoparticles as Highly Efficient Photoacoustic Agents for Deep Brain Tumor Imaging in Living Mice," by Quli Fan, PhD, et al. from the Cancer Molecular Imaging Chemistry Lab was highlighted by Advanced Materials as the Inside Cover.

Read the abstract
View the Advanced Materials Inside Cover

Stanford Publishes First Clinical Paper Reporting the Use of Simultaneous PET/MRI with Time-of-flight Capability in Cancer Patients

cnm-cover_40-1.jpgA group of collaborators from MIPS, MRI and Nuclear Medicine sections in the Department of Radiology at Stanford University published the first clinical paper reporting the use of a novel simultaneous PET/MRI scanner with time-of-flight capability in cancer patients. Data was collected using a scanner produced by GE Healthcare and installed first worldwide at Stanford. The initial experience with this PET/MR system has shown that the TOF PET is capable of excellent performance during simultaneous PET/MR with routine pulse sequences. MR imaging was not compromised. This opens a new world of collaborations to advance science across multiple specialties. An image from this article is featured on the cover of the January 2015 issue of Clinical Nuclear Medicine (official journal of the American College of Nuclear Medicine).

Read the Clinical Nuclear Medicine article

New Study Imaging Alzheimers Disease Therapy Response Received Media Coverage

micro PET scan using 18FGE-18Michelle James, PhD, an Instructor in the Multimodality Molecular Imaging Lab (MMIL), presented research at the Society for Neuroscience meeting that used the PET imaging tracer [18F]GE-180 to image the effects of treatment with an investigational oral compound, LM11A-31, known to target the p75 neurotrophin receptor. In the studies [18F]GE-180 was able to detect a therapeutic effect in APP-transgenic mice treated with LM11A-31, demonstrating the potential of [18F]GE-180 to serve as a sensitive and accurate tool for monitoring response to therapies that attenuate microglial activation.

The research was highlighted in AlzForum and Neurology Today.

Read the abstract
Read the AlzForum article
Read the Neurology Today article

Stanford Neuroradiology Discovers Abnormalities in the Brain of Chronic Fatigue Syndrome

Neuroradiological imaging of chronic fatigue syndromeUsing diffusion tensor imaging and quantitative volumetric imaging, Dr. Michael Zeineh and colleagues interrogated brain structure and microstructure in chronic fatigue syndrome (CFS). They discovered both focal and global abnormalities in white matter in the brain (white matter is the cabling deep in the brain). There was less white matter in the brain overall in CFS, and a track in the right hemisphere called the arcuate fasciculus was focally abnormal in CFS. This landmark study opens the door to new investigations that should lead to therapy for chronic fatigue syndrome.

View the New York Times article
Watch the ABC newscast
View the CNN article

Hossein Nejadnik Received 2014 RSNA Trainee Research Prize

Photo of Hossein NejadnikPhoto of Hossein Nejadnik

Hossein Nejadnik, MD, PhD, a postdoctoral fellow in the Daldrup-Link Lab, received a Trainee Research Prize from the 2014 RSNA Annual Meeting for the study, "Diagnosis of Stem Cell Apoptosis in Arthritic Joints with MRI".

The Trainee Prize was created in 1994 by the RSNA Program Committee to recognize the contribution of residents to the RSNA Scientific Assembly and Annual Meeting. In later years it was expanded to include fellows and medical students and in 2005 was renamed Trainee Research Prize.

Congratulations, Hossein!

Dr. Gambhir Named Fellow of American Association for the Advancement of Science (AAAS)

Photo of Sanjiv Sam GambhirPlease join us in congratulating Department Chair Dr. Sanjiv Sam Gambhir who has been named an American Association for the Advancement of Science (AAAS) Fellow. This honor is bestowed on AAAS members by their peers for meritorious efforts to advance science or its applications.

The accomplishments of the new Fellows will be celebrated at the 2015 AAAS Annual Meeting, convening this year under the theme "Innovations, Information, and Imaging." At the Annual Meeting, the new Fellows will be presented with an official certificate and a gold and blue (representing science and engineering, respectively) rosette pin on Saturday, 14 February from 8:00 a.m. to 10:00 a.m. at the AAAS Fellows Forum in San Jose, California.

Read the AAAS Announcement
Read the Stanford Announcement

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