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Department of Radiology

Stanford Research Uses Tumor-activatable Minicircles for Early Detection of Cancer

Concept illustration of tumor-activatable minicirclesNew work from the Gambhir Lab published in PNAS uses a unique strategy to force tumor cells (if they exist) to produce a blood biomarker that would otherwise not be present. This approach holds significant promise as a new way to tackle the early detection of cancer because it is not dependent on molecules that cancer cells naturally shed that enter the blood.

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Research Featured as the Inside Cover in the Advanced Materials

AM-cover-150204.jpgThe paper entitled "Perylene-Diimide-Based Nanoparticles as Highly Efficient Photoacoustic Agents for Deep Brain Tumor Imaging in Living Mice," by Quli Fan, PhD, et al. from the Cancer Molecular Imaging Chemistry Lab was highlighted by Advanced Materials as the Inside Cover.

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Stanford Publishes First Clinical Paper Reporting the Use of Simultaneous PET/MRI with Time-of-flight Capability in Cancer Patients

cnm-cover_40-1.jpgA group of collaborators from MIPS, MRI and Nuclear Medicine sections in the Department of Radiology at Stanford University published the first clinical paper reporting the use of a novel simultaneous PET/MRI scanner with time-of-flight capability in cancer patients. Data was collected using a scanner produced by GE Healthcare and installed first worldwide at Stanford. The initial experience with this PET/MR system has shown that the TOF PET is capable of excellent performance during simultaneous PET/MR with routine pulse sequences. MR imaging was not compromised. This opens a new world of collaborations to advance science across multiple specialties. An image from this article is featured on the cover of the January 2015 issue of Clinical Nuclear Medicine (official journal of the American College of Nuclear Medicine).

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New Study Imaging Alzheimers Disease Therapy Response Received Media Coverage

micro PET scan using 18FGE-18Michelle James, PhD, an Instructor in the Multimodality Molecular Imaging Lab (MMIL), presented research at the Society for Neuroscience meeting that used the PET imaging tracer [18F]GE-180 to image the effects of treatment with an investigational oral compound, LM11A-31, known to target the p75 neurotrophin receptor. In the studies [18F]GE-180 was able to detect a therapeutic effect in APP-transgenic mice treated with LM11A-31, demonstrating the potential of [18F]GE-180 to serve as a sensitive and accurate tool for monitoring response to therapies that attenuate microglial activation.

The research was highlighted in AlzForum and Neurology Today.

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Stanford Neuroradiology Discovers Abnormalities in the Brain of Chronic Fatigue Syndrome

Neuroradiological imaging of chronic fatigue syndromeUsing diffusion tensor imaging and quantitative volumetric imaging, Dr. Michael Zeineh and colleagues interrogated brain structure and microstructure in chronic fatigue syndrome (CFS). They discovered both focal and global abnormalities in white matter in the brain (white matter is the cabling deep in the brain). There was less white matter in the brain overall in CFS, and a track in the right hemisphere called the arcuate fasciculus was focally abnormal in CFS. This landmark study opens the door to new investigations that should lead to therapy for chronic fatigue syndrome.

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Hossein Nejadnik Received 2014 RSNA Trainee Research Prize

Photo of Hossein NejadnikPhoto of Hossein Nejadnik

Hossein Nejadnik, MD, PhD, a postdoctoral fellow in the Daldrup-Link Lab, received a Trainee Research Prize from the 2014 RSNA Annual Meeting for the study, "Diagnosis of Stem Cell Apoptosis in Arthritic Joints with MRI".

The Trainee Prize was created in 1994 by the RSNA Program Committee to recognize the contribution of residents to the RSNA Scientific Assembly and Annual Meeting. In later years it was expanded to include fellows and medical students and in 2005 was renamed Trainee Research Prize.

Congratulations, Hossein!

Dr. Gambhir Named Fellow of American Association for the Advancement of Science (AAAS)

Photo of Sanjiv Sam GambhirPlease join us in congratulating Department Chair Dr. Sanjiv Sam Gambhir who has been named an American Association for the Advancement of Science (AAAS) Fellow. This honor is bestowed on AAAS members by their peers for meritorious efforts to advance science or its applications.

The accomplishments of the new Fellows will be celebrated at the 2015 AAAS Annual Meeting, convening this year under the theme "Innovations, Information, and Imaging." At the Annual Meeting, the new Fellows will be presented with an official certificate and a gold and blue (representing science and engineering, respectively) rosette pin on Saturday, 14 February from 8:00 a.m. to 10:00 a.m. at the AAAS Fellows Forum in San Jose, California.

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Shannon Walters wins 2014 Aunt Minnie Award for Best Radiologic Technologist Educator

Screen Shot 2014-10-31 at 9.57.01 AM.pngStanford Radiology's Shannon Walters, co-manager of the 3DQ Lab has won the 2014 Aunt Minnie Award for Best Radiologic Technologist Educator. Congratulations Shannon!

Aunt Minnie's press release:
"Best Radiologic Technologist Educator
Winner: Shannon Walters, Stanford University

As one of the three co-managers of the 3D and Quantitative Imaging (3DQ) Lab at Stanford University, Shannon Walters is heavily involved in the training and education of technologists who are rotating through the facility.

Walters first became a radiologic technologist during a stint in the U.S. Army from 1997-2003, where he handled MRI duties at Walter Reed Army Medical Center, among other locations. Upon reentering civilian life, he became an MRI technologist at Stanford, left the university for a job as a 3D technologist in Michigan, and finally returned to Stanford, becoming co-manager of the lab 18 months ago.

Walters enjoys the fact that 3D technologists are on the cutting edge of technology, using high-tech methods to solve the clinical problems of the day, such as helping colleagues in the catheterization lab get C-arm angles faster.

Technologists working in the 3DQ lab at Stanford have slowly been expanding their responsibilities, taking over duties once performed by radiologists, such as vascular measurements.

"Technologists are able to take over knowledge and processes from the radiologist and do them in a reliable manner," he said. "We are right there, able to solve problems right now; we are able to do it ourselves."

Working in 3D is key to the expanding role of technologists in healthcare, Walters believes. While technologists performing CT and MRI scans are helping to answer specific clinical questions, such as by ruling out disease, 3D technologists are going a step further by helping to demonstrate the pathology in an image.

"I like the fact that we are on the edge of technology, and we are pushing it every single day," he said.

Radiology Researchers find Brain Abnormalities in Chronic Fatigue Patients

DSC_0696_4x5.jpgDr. Zeineh was the lead author on a study that found distinct differences between the brain images of patients with chronic fatigue syndrome versus their healthy counterparts.
Additional co-authors are former fellow James Kang, MD; former professor of radiology and neuroradiology chief, Scott Atlas, MD; professor of radiology and psychiatry and behavioral sciences Allan Reiss, MD; and senior author Jose Montoya, MD, professor of infectious diseases and geographic medicine.
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Center for Advanced Magnetic Resonance Technology at Stanford (CAMRT) Well-received by NIH Visitors

DSC_7027-large.jpgGary Gloverís longstanding MR Technology NIBIB center program received a nearly perfect score after an NIH/NIBIB site visit this week aimed at reviewing the renewal of the program for another 5 years.

Dr. Glover learned of the exceptional outcome yesterday morning around 10AM and has not stopped smiling since then. The renewal of this grant will support the CAMRT team out to 2020. Congratulations to Gary, Dan Spielman, John Pauly, Brian Hargreaves, Brian Rutt, Mike Moseley, and the staff and students supporting this amazingly productive program.

At nearly 20 years, this is our longest running NIH-funded Center Program in the Department and the 2nd longest NIH award in the Department.

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