Radiology

Scan Times

Weblog of the Department of Radiology

Announcements: February 1, 2008

Posted 8:12 AM, February 1, 2008, by jaruiz

Special Research Conference with Dr. Bitton: Monday, February, 4, 2008, at 4:00PM in the Lucas Learning Center (Lucas expansion, basement level), P083.
The MIPS Molecular Imaging Seminar Series Presents Robin P. Choudhury, MA, DM, MRCP: Monday, February 4, 2008, in the School of Medicine's Alway Building, room M114, at 4:30-5:15 PM, followed by a discussion from 5:15-5:30 PM, and a reception from 5:30-6:00 PM.

Special Research Conference with Dr. Bitton: Monday, February, 4, 2008 at 4:00PM in the Lucas Learning Center (Lucas expansion, basement level), P083. Dr. Rachel Bitton will be presenting a talk entitled "A High Frequency Array-Based Photoacoustic Microscopy System for Non-Invasive Vascular Imaging." Dr. Bitton recently received her PhD in biomedical engineering from the University of Southern California. Please find the abstract for her talk below. If you have questions, please contact Donna Cronister.


ABSTRACT:
The development of new approaches to biomedical imaging is fueled by the manifest need for high speed, high resolution, non-invasive techniques able to visualize high contrast tissue structures such as microvessels. Laser induced high frequency photoacoustic microscopy is a hybrid imaging modality based on the intrinsic optical properties of biological tissue and ultrasonic detection at high frequencies (>20MHz). In this talk, a novel design for a photoacoustic imaging system using a 30MHz transducer array and 16 channel custom receive electronics is presented. This system is able to produce photoacoustic images of phantoms, as well as small animal microvasculature in-vivo. The applications for this type of photoacoustic microscopy can extend to real-time high frequency imaging, functional imaging, and multi-modal capabilities by overlaying ultrasonic and photoacoustic images, while offering a unique prospect to visualize cancer-related angiogenesis.


The MIPS Molecular Imaging Seminar Series Presents Robin P. Choudhury, MA, DM, MRCP: Monday, February 4, 2008, in the School of Medicine's Alway Building, room M114, at 4:30-5:15 PM, followed by a discussion from 5:15-5:30 PM, and a reception from 5:30-6:00 PM. Dr. Choudhury is a Wellcome Trust Intermediate Clinical Research Fellow and honorary consultant radiologist at John Radcliffe Hospital, Oxford. She will present a seminar entitled "Microparticles of Iron Oxide for Molecular MRI." Please find her abstract below. Her talk is sponsored by the Molecular Imaging Program at Stanford (MIPS); hosted by Sanjiv Sam Gambhir, MD, PhD, and Edward Graves, PhD; and supported by Philips. If you have questions, please contact Susan Singh.


ABSTRACT:
Micro-particles of iron oxide (MPIO) have been used for cellular imaging and tracking. For some molecular imaging applications, the size of these particles would preclude delivery to the site of interest. However, for imaging endovascular targets, MPIO possess several positive attributes. Firstly, MPIO conveys a payload of iron that is orders of magnitude greater than ultra-small particles of iron oxide (USPIO). Secondly, the effects of MPIO on local magnetic field homogeneity, and therefore detectable contrast, extend a distance many times their physical diameter. Thirdly, once bound to endothelium, MPIO remain intravascular, thereby allowing bound MPIO to be readily distinguished from the vessel wall. Finally, conjugated MPIO may offer a generic tool for imaging endothelial-specific markers across a range of vascular pathologies. Accordingly, we have adopted a MPIO-based approach for targeted MRI and applied this to the detection of adhesion molecules on the arterial endothelium (atherosclerosis and brain inflammation) and activated platelets (arterial thrombosis and cerebral malaria).

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