Dr. Gary M. Glazer and Colleagues Use Image-Guided Insonification for Tumor Biomarker Detection

Emma Pfeiffer Merner Professor in the Medical Sciences and chair of the Department of Radiology, Gary M. Glazer, MD, led a team of researchers in a ground-breaking study recently published in Proceedings of the National Academy of Sciences (PNAS), "A Strategy for Blood Biomarker Amplification and Localization Using Ultrasound," in which they apply low-frequency ultrasound directly to tumor cells, causing the release of significant amounts of biomarker measurable in the blood. Simultaneously, they provide a method for the localization of biomarker production by showing that this release of biomarkers is specific to the direct application of ultrasound to the tumor. Their research is featured in a recent Stanford news article by Bruce Goldman, "Researchers Use Ultrasound to Better Detect Tumor Biomarkers."

Dr. Glazer published his study along with co-author, Sanjiv "Sam" Gambhir, MD, PhD, Virginia & D.K. Ludwig Professor of Radiology & Bioengineering; chief of the Nuclear Medicine Division; and director of the Molecular Imaging Program at Stanford (MIPS), as well as first author Aloma D'Souza, PhD, research scientist and member of the Multimodality Molecular Imaging Lab. Other co-authors include Kim Butts Pauly, PhD, professor of radiology; Samira Guccione, PhD, assistant professor of radiology; and staff scientists Jeffrey Tseng, MD (now at Santa Clara Valley Medical Center in California) and Jarrett Rosenberg, PhD, of the radiology department.

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